If you'd limit yourself to cores implementing the Application profile of ARM (Armv8-A etc), you'd do the same and limit yourself to cores implementing the Application profile of RISC-V (RVA23 etc). In that case, you can assume vector instructions and everything else.
If you don't, you get the exact same kind of question with ARM as with RISC-V. Do you use NEON or with SVE? Or do you conservatively compile without vector instructions at all even though it could possibly result in speed-ups for some loops?
Micropython runs on tons of stuff and while it isnt capital-P Python, its close enough for doing a wide variety of embedded work without learning a new language/libraries/etc.
If you don't, you get the exact same kind of question with ARM as with RISC-V. Do you use NEON or with SVE? Or do you conservatively compile without vector instructions at all even though it could possibly result in speed-ups for some loops?